LAST MEETING: When these two sides faced each other back in December it finished 2-2. Relive the main moments.
So, this evening's teams are in - and it's four changes for the R's following Saturday's stalemate at Cardiff City. Alex Smithies, James Perch, Junior Hoilett and Conor Washington are in for Matt Ingram, Paul Konchesky, Tjaronn Chery and Seb Polter respectively.
Here's how our hosts are lining up tonight ...
The teams are in the tunnel ...
KICK-OFF: We're off and underway at the Amex!
5 mins: There's some atmosphere present here already. Rangers have seemingly brought with them a healthy away following from west London. [0-0]
7 mins: R's supporters have just joined in with a minute's applause for lifelong Brighton fan Dennis Caesar, 92, who sadly passed away following Albion's 5-0 thrashing of Fulham on Friday night. May he rest in peace. [0-0]
11 mins: It's been a decent start from the Super Hoops, who have settled relatively well. Ale Faurlin has just skewed over from 20 yards. [0-0]
18 mins: Brighton go close. James Wilson breaks away down the left and his cross is to a tee for Anthony Knockaert, who somehow heads over from six yards. [0-0]
19 mins: The R's threaten a minute later. Matt Phillips swipes at an effort but it falls to Conor Washington in the box, who thumps his shot just over! [0-0]
22 mins: First booking of the evening. Albion man Jiri Skalak is penalised for a late challenge on Grant Hall. [0-0]
26 mins: Series of strong challenges going in here! Good, competitive edge to this contest. [0-0]
28 mins: QPR's Clint Hill heads at David Stockdale from an Ale Faurlin corner. [0-0]
30 mins: Brighton's Tomer Hemed sends an acrobatic effort looping over. [0-0]
31 mins: Albion goalkeeper David Stockdale dives low to palm away Matt Phillips' low drive. [0-0]
34 mins: James Wilson lashes only inches wide for Brighton. However, Rangers are more than playing their part in a good game of football currently. [0-0]
40 mins: So close! Matt Phillips fires just past the upright for QPR, after fine approach play. [0-0]
41 mins: Alex Smithies saves on the goal-line to deny Brighton's Lewis Dunk, from a home corner kick. [0-0]
45+1 mins: One minute of stoppage time added on. [0-0]
45+1 mins: Goal. Rangers fall behind. It's a fine effort from Brighton's Anthony Knockaert, who curls a 25-yard free-kick beyond Alex Smithies and into the top right-hand corner. [1-0]
HALF-TIME: The interval arrives - and you've got to say that Rangers don't really deserve to be behind. It's been a fast-paced encounter thus far, and Jimmy Floyd Hasselbaink's men have more than matched the hosts. Anthony Knockaert's lovely free-kick goal on the stroke of half-time is the difference here. The second half is coming up ...
The teams are back out for the second half ...
SECOND HALF: We're back underway here. Brighton have replaced James Wilson with Sam Baldock at the half-time break. Come on you R's! [1-0]
47 mins: Tonight's attendance has been announced. It's 25,411, with 1,109 Rangers fans present. Great travelling support in midweek from R's supporters. [1-0]
50 mins: No chances of note inside the first five minutes of the second half. [1-0]
51 mins: Goal. Brighton go two up - but you have to take your hat off to Jiri Skalak, who fires home emphatically on the half-volley following Grant Hall's headed clearance. Rangers are behind to two simply stunning efforts. [2-0]
54 mins: QPR introduce Seb Polter for Junior Hoilett. [2-0]
59 mins: Change number two soon follows for the Hoops. Tjaronn Chery replaces Clint Hill. [2-0]
61 mins: Massimo Luongo blasts over, as Rangers go in search of a reply. [2-0]
65 mins: A period of calm has ensued. Jimmy Floyd Hasselbaink and his charges must be wondering how they're two goals behind. [2-0]
70 mins: Third and final R's substitution, as Nasser El Khayati comes on for Conor Washington. Meanwhile, Brighton have replaced goalscorer Jiri Skalak with Jamie Murphy. [2-0]
71 mins: QPR's Mass Luongo goes into the book for a foul on Tomer Hemed. [2-0]
73 mins: Goal. Connor Goldson heads Albion into a three-goal lead, following Anthony Knockaert's left-wing corner. [3-0]
77 mins: Brighton make their final change, with Steve Sidwell now on for Tomer Hemed. That sub comes shortly after Seb Polter headed just past the post for the R's. [3-0]
81 mins: Brighton's Connor Goldson spurns the chance to test Alex Smithies from 20 yards, blasting over. [3-0]
83 mins: Tjaronn Chery blasts over for Rangers, after Matt Phillips' corner eventually falls into his path on the edge of the box. [3-0]
84 mins: Goal. That's four for Brighton, as Anthony Knockaert's 18-yard effort squirms past Alex Smithies and into the bottom left-hand corner. [4-0]
88 mins: Tjaronn Chery thumps another effort beyond the target for QPR. [4-0]
90+1 mins: Four minutes of injury time have been signalled by the fourth official. [4-0]
90+1 mins: Rangers' Seb Polter is shown a yellow card for a late tackle. [4-0]
90+2 mins: Matt Phillips' attempt from range for the R's fizzes just over the crossbar. [4-0]